阿尔茨海默氏病是一种进行性神经退行性疾病，逐渐剥夺患者的认知功能，并可能以死亡结束。随着当今技术的发展，可以通过磁共振成像（MRI）扫描来检测阿尔茨海默氏病。因此，MRI是最常用于诊断和分析阿尔茨海默氏病进展的技术。有了这项技术，可以使用机器学习自动实现对阿尔茨海默氏病的早期诊断的图像识别。尽管机器学习具有许多优势，但目前使用深度学习的应用更广泛地应用，因为它具有更强的学习能力，并且更适合解决图像识别问题。但是，仍然存在一些挑战以实施深度学习，例如对大型数据集的需求，需要大量的计算资源以及需要仔细的参数设置以防止过度拟合或不足。在应对使用深度学习对阿尔茨海默氏病进行分类的挑战时，本研究提出了使用残留网络18层（RESNET-18）体系结构的卷积神经网络（CNN）方法。为了克服对大型且平衡的数据集的需求，使用来自ImageNet的传输学习并加权损耗函数值，以使每个类具有相同的权重。而且，在这项研究中，通过将网络激活函数更改为MISH激活函数以提高准确性，从而进行了实验。从已经进行的测试结果中，使用转移学习，加权损失和MISH激活函数的模型准确性为88.3％。该准确性值来自基线模型，仅获得69.1％的精度。

Diabetic Retinopathy (DR) is considered one of the primary concerns due to its effect on vision loss among most people with diabetes globally. The severity of DR is mostly comprehended manually by ophthalmologists from fundus photography-based retina images. This paper deals with an automated understanding of the severity stages of DR. In the literature, researchers have focused on this automation using traditional machine learning-based algorithms and convolutional architectures. However, the past works hardly focused on essential parts of the retinal image to improve the model performance. In this paper, we adopt transformer-based learning models to capture the crucial features of retinal images to understand DR severity better. We work with ensembling image transformers, where we adopt four models, namely ViT (Vision Transformer), BEiT (Bidirectional Encoder representation for image Transformer), CaiT (Class-Attention in Image Transformers), and DeiT (Data efficient image Transformers), to infer the degree of DR severity from fundus photographs. For experiments, we used the publicly available APTOS-2019 blindness detection dataset, where the performances of the transformer-based models were quite encouraging.

This paper presents our solutions for the MediaEval 2022 task on DisasterMM. The task is composed of two subtasks, namely (i) Relevance Classification of Twitter Posts (RCTP), and (ii) Location Extraction from Twitter Texts (LETT). The RCTP subtask aims at differentiating flood-related and non-relevant social posts while LETT is a Named Entity Recognition (NER) task and aims at the extraction of location information from the text. For RCTP, we proposed four different solutions based on BERT, RoBERTa, Distil BERT, and ALBERT obtaining an F1-score of 0.7934, 0.7970, 0.7613, and 0.7924, respectively. For LETT, we used three models namely BERT, RoBERTa, and Distil BERTA obtaining an F1-score of 0.6256, 0.6744, and 0.6723, respectively.

Objective: Despite numerous studies proposed for audio restoration in the literature, most of them focus on an isolated restoration problem such as denoising or dereverberation, ignoring other artifacts. Moreover, assuming a noisy or reverberant environment with limited number of fixed signal-to-distortion ratio (SDR) levels is a common practice. However, real-world audio is often corrupted by a blend of artifacts such as reverberation, sensor noise, and background audio mixture with varying types, severities, and duration. In this study, we propose a novel approach for blind restoration of real-world audio signals by Operational Generative Adversarial Networks (Op-GANs) with temporal and spectral objective metrics to enhance the quality of restored audio signal regardless of the type and severity of each artifact corrupting it. Methods: 1D Operational-GANs are used with generative neuron model optimized for blind restoration of any corrupted audio signal. Results: The proposed approach has been evaluated extensively over the benchmark TIMIT-RAR (speech) and GTZAN-RAR (non-speech) datasets corrupted with a random blend of artifacts each with a random severity to mimic real-world audio signals. Average SDR improvements of over 7.2 dB and 4.9 dB are achieved, respectively, which are substantial when compared with the baseline methods. Significance: This is a pioneer study in blind audio restoration with the unique capability of direct (time-domain) restoration of real-world audio whilst achieving an unprecedented level of performance for a wide SDR range and artifact types. Conclusion: 1D Op-GANs can achieve robust and computationally effective real-world audio restoration with significantly improved performance. The source codes and the generated real-world audio datasets are shared publicly with the research community in a dedicated GitHub repository1.

Uncertainty quantification is crucial to inverse problems, as it could provide decision-makers with valuable information about the inversion results. For example, seismic inversion is a notoriously ill-posed inverse problem due to the band-limited and noisy nature of seismic data. It is therefore of paramount importance to quantify the uncertainties associated to the inversion process to ease the subsequent interpretation and decision making processes. Within this framework of reference, sampling from a target posterior provides a fundamental approach to quantifying the uncertainty in seismic inversion. However, selecting appropriate prior information in a probabilistic inversion is crucial, yet non-trivial, as it influences the ability of a sampling-based inference in providing geological realism in the posterior samples. To overcome such limitations, we present a regularized variational inference framework that performs posterior inference by implicitly regularizing the Kullback-Leibler divergence loss with a CNN-based denoiser by means of the Plug-and-Play methods. We call this new algorithm Plug-and-Play Stein Variational Gradient Descent (PnP-SVGD) and demonstrate its ability in producing high-resolution, trustworthy samples representative of the subsurface structures, which we argue could be used for post-inference tasks such as reservoir modelling and history matching. To validate the proposed method, numerical tests are performed on both synthetic and field post-stack seismic data.

In recent years distributional reinforcement learning has produced many state of the art results. Increasingly sample efficient Distributional algorithms for the discrete action domain have been developed over time that vary primarily in the way they parameterize their approximations of value distributions, and how they quantify the differences between those distributions. In this work we transfer three of the most well-known and successful of those algorithms (QR-DQN, IQN and FQF) to the continuous action domain by extending two powerful actor-critic algorithms (TD3 and SAC) with distributional critics. We investigate whether the relative performance of the methods for the discrete action space translates to the continuous case. To that end we compare them empirically on the pybullet implementations of a set of continuous control tasks. Our results indicate qualitative invariance regarding the number and placement of distributional atoms in the deterministic, continuous action setting.

Automated synthesis of histology images has several potential applications in computational pathology. However, no existing method can generate realistic tissue images with a bespoke cellular layout or user-defined histology parameters. In this work, we propose a novel framework called SynCLay (Synthesis from Cellular Layouts) that can construct realistic and high-quality histology images from user-defined cellular layouts along with annotated cellular boundaries. Tissue image generation based on bespoke cellular layouts through the proposed framework allows users to generate different histological patterns from arbitrary topological arrangement of different types of cells. SynCLay generated synthetic images can be helpful in studying the role of different types of cells present in the tumor microenvironmet. Additionally, they can assist in balancing the distribution of cellular counts in tissue images for designing accurate cellular composition predictors by minimizing the effects of data imbalance. We train SynCLay in an adversarial manner and integrate a nuclear segmentation and classification model in its training to refine nuclear structures and generate nuclear masks in conjunction with synthetic images. During inference, we combine the model with another parametric model for generating colon images and associated cellular counts as annotations given the grade of differentiation and cell densities of different cells. We assess the generated images quantitatively and report on feedback from trained pathologists who assigned realism scores to a set of images generated by the framework. The average realism score across all pathologists for synthetic images was as high as that for the real images. We also show that augmenting limited real data with the synthetic data generated by our framework can significantly boost prediction performance of the cellular composition prediction task.

Autonomous mobile agents such as unmanned aerial vehicles (UAVs) and mobile robots have shown huge potential for improving human productivity. These mobile agents require low power/energy consumption to have a long lifespan since they are usually powered by batteries. These agents also need to adapt to changing/dynamic environments, especially when deployed in far or dangerous locations, thus requiring efficient online learning capabilities. These requirements can be fulfilled by employing Spiking Neural Networks (SNNs) since SNNs offer low power/energy consumption due to sparse computations and efficient online learning due to bio-inspired learning mechanisms. However, a methodology is still required to employ appropriate SNN models on autonomous mobile agents. Towards this, we propose a Mantis methodology to systematically employ SNNs on autonomous mobile agents to enable energy-efficient processing and adaptive capabilities in dynamic environments. The key ideas of our Mantis include the optimization of SNN operations, the employment of a bio-plausible online learning mechanism, and the SNN model selection. The experimental results demonstrate that our methodology maintains high accuracy with a significantly smaller memory footprint and energy consumption (i.e., 3.32x memory reduction and 2.9x energy saving for an SNN model with 8-bit weights) compared to the baseline network with 32-bit weights. In this manner, our Mantis enables the employment of SNNs for resource- and energy-constrained mobile agents.

In this paper, we present an evolved version of the Situational Graphs, which jointly models in a single optimizable factor graph, a SLAM graph, as a set of robot keyframes, containing its associated measurements and robot poses, and a 3D scene graph, as a high-level representation of the environment that encodes its different geometric elements with semantic attributes and the relational information between those elements. Our proposed S-Graphs+ is a novel four-layered factor graph that includes: (1) a keyframes layer with robot pose estimates, (2) a walls layer representing wall surfaces, (3) a rooms layer encompassing sets of wall planes, and (4) a floors layer gathering the rooms within a given floor level. The above graph is optimized in real-time to obtain a robust and accurate estimate of the robot's pose and its map, simultaneously constructing and leveraging the high-level information of the environment. To extract such high-level information, we present novel room and floor segmentation algorithms utilizing the mapped wall planes and free-space clusters. We tested S-Graphs+ on multiple datasets including, simulations of distinct indoor environments, on real datasets captured over several construction sites and office environments, and on a real public dataset of indoor office environments. S-Graphs+ outperforms relevant baselines in the majority of the datasets while extending the robot situational awareness by a four-layered scene model. Moreover, we make the algorithm available as a docker file.

This article presents a novel review of Active SLAM (A-SLAM) research conducted in the last decade. We discuss the formulation, application, and methodology applied in A-SLAM for trajectory generation and control action selection using information theory based approaches. Our extensive qualitative and quantitative analysis highlights the approaches, scenarios, configurations, types of robots, sensor types, dataset usage, and path planning approaches of A-SLAM research. We conclude by presenting the limitations and proposing future research possibilities. We believe that this survey will be helpful to researchers in understanding the various methods and techniques applied to A-SLAM formulation.